Out of the many many many many many many many many many many many many many pieces of pony fan art created by multiple super talented artist in our fandom, the Dogs Playing Poker crossover by harwicks is all time favorite. It also happens to be my personal favorite painting as well https://harwicks-art.deviantart.com/art/Know-When-to-Fold-Em-274057023
This piece, hands down. It was one of the first pieces of MLP Art I’ve seen on the Internet when I first entered the fandom. Brings me back to my early high school years and it gives me such nostalgia.
I have plenty of favorite pieces of artwork with lots of different characters.
To be honest I can’t choose only one top best artwork.
But I can tell you what’s the best that came on my mind right now, and it is this one here