So looking at it, I decided to add a few things to my college idea.
Edited Idea:
The Mane 6 (Twilight, Rainbow Dash, Rarity, AppleJack, Pinkie Pie and Fluttershy), Fightin 6 (Oleander, Arizona, Tianhuo, Paprika, Pom and Velvet), Reformed Unicorn Group (Starlight, Trixie, Fizzlepop and Sunset), Background 3 (Derpy, Lyra and Bon-Bon) and the Star 5 (Sunny, Izzy, Hitch, Zipp and Pipp) attend college.
Based on
this, this, and this.
With shades of Degrassi and Boy meets world.
The college would be The University of South Florida.