Frantically make and drink nitroglycerin/insulin smoothie, ask if she knows how the hell she’s there, explain what hell is, assure her ponies don’t go there, hug until terror subsides.

Make an oath to protect her from all evil.

“No pulling the blankets or hogging the bed, or you go sleep on the couch. Now go back to sleep, today is a national holiday and I get to sleep in.”  
(Well, it is HERE…)

Oh, my long missing teddy bear plushie!
 
Thank you, unkonwn miniature horse!

…Did I do something horrible last night?

Call Rarity and tell her to keep a better eye on her sister. :I
 
…or scold Apple Bloom for some reason. It’s 2:30 in the morning. Tired.

@The Smiling Pony  
You misspelt Twilight Sparkle. Trixie is second best pony.

@Randomosaur  
Trixie might be Best Pony, but that doesn’t mean other ponies are Pretty Damn Good.

Move to my other bed.  
I have two beds in my room in case something like this happens.
 
Be prepared.

@The Smiling Pony  
And then you realize she isn’t Trixie.

Hug.  
Also cry and whimper a little. Sobbing optional.

Find a Spike and begin shipping.
 
While that’s happening, I’ll hug her.

@cromwell20  

……hugs