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Description

Derpy has too much derpamine in her herpathalamus. It’s a serious medical condition.

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Background Pony Number 17
My Little Pony - 1992 Edition

I’ve always thought “derp” was a medical condition that afflicts ponies from time to time. Symptoms include the eyes going out of alignment, loss of physical coordination, and mental confusion.
 
Fortunately, although a common ailment, it’s rarely persistent, and ponies usually recover from it quickly. Poor Derpy, however, has a chronic case of it that seems to defy all attempts at treatment.