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safe2255011 applejack207069 fluttershy267792 pinkie pie264670 rainbow dash289209 rarity224813 twilight sparkle369518 earth pony540300 pegasus530914 pony1686413 unicorn575208 g42115185 artifact1877 caption26662 crazy face1318 cutie mark failure insanity syndrome9 derp8635 faic15172 flanderization77 flutterrage606 happy46927 image macro40501 impact font1967 insanity3506 mane six38703 meme96383 my little brony138 pinkamena diane pie23161 seasonal rot4 smiling427512 text95595 twilight snapple2406 twilighting445 unicorn twilight37003 watermark25465 you're going to love me278

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infinita est lux Solis
Artist -

Heretical Inquisitor
@Nashrakh
Hmm, if it were canon, would it merely be psychosomatic or a legit physiological condition… Like, it could be that the reason ponies go insane when they can’t fulfill their talents is because of how ponies are raised to take an immense amount of pride in their cutie marks to the point that I could see them going insane purely as a result of the societal pressures imposed upon them. but I can also see the cutie mark’s magic slowly ablating away at the pony’s mental state if they can’t live up to the talents dictated to them by their mark, therefore regardless of how the pony was raised they would still slowly go insane if prevented from doing what they’re magically gifted at.
Nashrakh

After all these years, I am still of the opinion that Cutie Mark Failure Insanity Syndrome is a real thing, and should be considered canon.