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Description

Blossom: I can’t make sense of this, but we seem to be ponies.
Bubbles: I have…hooves!
Buttercup: This is totally lame.
Twilight: Don’t worry, girls. I’ll find a spell to fix this, but I’m a human now.
Fluttershy: I… Ummm… I’ll just wait this out…
Rainbow Dash: What the hoof is going on!? This is so not awesome!

safe2222648 artist:bast-incarnation2 fluttershy264180 rainbow dash285664 twilight sparkle364834 human257949 pegasus518211 pony1652984 unicorn561193 g42082899 bipedal51311 blossom (powerpuff girls)366 bow46909 bubbles (powerpuff girls)445 buttercup (powerpuff girls)344 confused6891 crossed hooves3030 crossover74290 female1858551 hair bow27029 horn217621 humanized122218 mare775923 multicolored hair13150 pigtails7008 ponified52196 powerpuffified81 rainbow hair5445 shocked10422 signature47129 species swap27700 spread wings100510 stars24587 the powerpuff girls1202 unamused24840 wings237381

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Drakin

Interesting fact for those unawair which is probably very few at this point.
The Cutie Mark Crusaders were initially designed to look like the Powerpuff Girls. Hence Apple Blooms big bow similar to the one Blossom has and Scootaloos scruffy hair and more tomboy personality similar to Buttercup.