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Beau Skunky
Friendship, Art, and Magic (2019) - Celebrated Derpibooru's seventh year anniversary with friends
Cool Crow - "Caw!" An awesome tagger
Magnificent Metadata Maniac - #1 Assistant
Artist -

Now comes super-sized!
@looking glass  
It seems more implied there was some kinda “medicine” in the needle.
 
This comic actually becomes a li’l funnier in hindsight now that Rumble was kinda a dick in a recent episode.
looking glass
Not a Llama - Happy April Fools Day!

@SlayerBVC
The joke, I believe, was that when you inject someone with air, they die when the bubble reaches their heart…
 
Also, Pulmonary Embolism. That’s when air in the blood vessels reaches the brain, interrupts the blood flow, and you die. So yeah, if that bubble reaches the heart or brain, you would probably die.
Greenjack
Not a Llama - Happy April Fools Day!
The End wasn't The End - Found a new home after the great exodus of 2012

@Rpground  
well, that’s just plain ol’ blood pressure at work there. the fluid pumping out keeps the air out until well after you’re alive enough to care about some air in your bloodstream. also, that’s why scabs tend to flake off outwards, though there are cases where a scab has caused a stroke; though those are usually in infants and the elderly.
Greenjack
Not a Llama - Happy April Fools Day!
The End wasn't The End - Found a new home after the great exodus of 2012

@Deserter  
it’s not just potentially fatal, it’s an almost one hundred percent death rate if you don’t go in for treatment BEFORE the stroke or heart attack it causes kills you. air causes blood to coagulate, so if you get air in your bloodstream it always results in a blood clot somewhere, and those usually end up in your brain.
Background Pony #561F
@SlayerBVC  
The joke, I believe, was that when you inject someone with air, they die when the bubble reaches their heart…
Background Pony #AB3A
“Doctor, there is a vial of magic enhanced estrogen missing from supply.”