Disclaimer: I don’t mean what fetish Nightmare Moon has as a character.
Each of the villains seems to have what I’ll call a “companion fetish”. That is, if you’re going to write a clopfic with them, it’s very easy to decide what kind it will be.
King Sombra: sexual slavery, maybe harems
Queen Chrysalis: oviposition, mind control, maybe bondage
Discord: corruption, hypnosis, mindbreak
Nightmare Moon: ?