@PlanetKiller  
@Arifproject  
@LightningBolt  
Adobe Fireworks CS6 master race :P
 
I typically only use two layers. One for the characters and foreground, and one for the background:  
 
The blurred bushes and Kalianne are on the front layer, and everything else is in the rear layer.
 
For stuff like this I use three:  
 
Her mane that droops in front of the Blueblood part is the forelayer (shared across states), the Blueblood part is the middle layer, the rest of Rarity and the background is on the rear layer (also shared) :P

@PlanetKiller  
Just use groups a lot, I find layers cumbersome to work with.

@LightningBolt  
I use layers in the wingermortis comic, for each comic. Otherwise I just use a single file for one or more images. I’ll also create backgrounds and bases in files to organize them then import them into whatever I’m working on.

@PlanetKiller  
Yes!
 
I don’t use layers tho.

@PlanetKiller  
Inkscape ftw XD
 
 
@Joey  
Yep, in a way XD
 
 
@JP  
Winamp is life ✌
 
 
@Badumsquish  
Lmao 😂 😂

Is that boulevard of broken dreams?

Ah, a fellow Winamp user.

Is this censored booping?

Fellow inkscape users unite!