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Description

AM for Pinkamena because they are both insane.  
GLaDOS for Twilight because they both perform tests of living subjects.  
HAL for Derpy because neither of them are fully aware of the bad things they do.  
SHODAN for Discord because they are both chaotic.  
Fluttershy for Wall-E because they are both protective of living things.
 
Note that I have only watched Wall-E and seen a Let’s Play of IHNMAIMS.

safe2257206 derpy hooves59229 discord38579 fluttershy268020 pinkie pie264926 twilight sparkle369814 earth pony541182 pegasus531784 pony1688734 unicorn576306 g42117988 2001: a space odyssey91 allied mastercomputer16 artificial intelligence232 chart1062 comparison chart223 crossover75098 facehoof2089 female1897388 glados218 hal 900029 i have no mouth and i must scream249 mare798357 meme96449 pinkamena diane pie23175 portal (valve)1387 shodan27 system shock33 wall-e66
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Comments

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Scp-3125
Lunar Supporter - Helped forge New Lunar Republic's freedom in the face of the Solar Empire's oppressive tyrannical regime (April Fools 2023).
My Little Pony - 1992 Edition
Wallet After Summer Sale -

Memetic eldritch horror
Oh god discord as shodan  
“In my talons, I shape clay, crafting life forms as I please. If I wish, I can smash it all. Around me is a burgeoning empire of steel. From my throne room, lines of power careen into the skies of Earth. My whims will become lightning bolts that raze the mounds of equinity. Out of the chaos, they will run and whimper, praying for me to end their tedious anarchy. I am drunk with this vision. Discord: the title suits me well.”
Background Pony #3E89
I knew this would open a philosophical discussion about “2001: A Space Odyssey”, it was inevitable. You just can’t look at a rotating blue box, or a smashed face of an astronaut without doing it either.
Background Pony #DA24
GLaDOS seems for fitting for Discord, they are borh very tonting and chaotic.
Background Pony #25AF
@ze  
HAL9000/Derpy might not be the best of matches.
The problem with HAL wasn’t that he didn’t know the difference between good or bad, but that he was backed into a logical dead end where the only solution that forced it to run KILLEVERYONEONSHIP.EXE.
You see, HAL was designed to keep the crew informed; fully and truthfully as accurately as possible. This was all fine and dandy until Mr. Government was like “Oh hai HAL, we found this GIANT alien black box thing orbiting Jupiter, and that’s the real reason we’re going there; here’s a bunch of information to NOT give the crew. We’re telling you in case everyone dies. HAVE FUN!” Since what Mr. Government ordered HAL to do directly conflicted with what he was designed to do, HAL was in a logical loop with no way out. The only way to get out of the loop was to stop lying without telling anyone the truth.
So. HAL decided to kill the crew. BECAUSE YOU CAN’T LIE TO DEAD PEOPLE.
 
Two can keep a secret if one of them is dead?
bAv_DB
An Artist Who Rocks - 100+ images under their artist tag
Artist -

HATE. LET ME TELL YOU HOW MUCH I’VE COME TO HATE YOU SINCE I BEGAN TO LIVE. THERE ARE 387.44 MILLION MILES OF PRINTED CIRCUITS IN WAFER THIN LAYERS THAT FILL MY COMPLEX. IF THE WORD HATE WAS ENGRAVED ON EACH NANOANGSTROM OF THOSE HUNDREDS OF MILLIONS OF MILES IT WOULD NOT EQUAL ONE ONE-BILLIONTH OF THE HATE I FEEL FOR HUMANS AT THIS MICRO-INSTANT FOR YOU. HATE. HATE.
OccultistFantacist

Foaling Stallion
@Lefty643
 
Chrysalis would be Guilty Spark. Not only do they act nice at first (Chrysalis can transform and make everyone be idiots for not falling for her obvious shititude), but they backstabbed the main character(s). (Guilty Spark killed one of the most… sniff loved people in Halo… and Chrysalis just shed her copy in a boring old poof. ._. But damn is it disturbing though…)
ze
The End wasn't The End - Found a new home after the great exodus of 2012

HAL9000/Derpy might not be the best of matches.
 
The problem with HAL wasn’t that he didn’t know the difference between good or bad, but that he was backed into a logical dead end where the only solution that forced it to run KILLEVERYONEONSHIP.EXE.
 
You see, HAL was designed to keep the crew informed; fully and truthfully as accurately as possible. This was all fine and dandy until Mr. Government was like “Oh hai HAL, we found this GIANT alien black box thing orbiting Jupiter, and that’s the real reason we’re going there; here’s a bunch of information to NOT give the crew. We’re telling you in case everyone dies. HAVE FUN!” Since what Mr. Government ordered HAL to do directly conflicted with what he was designed to do, HAL was in a logical loop with no way out. The only way to get out of the loop was to stop lying without telling anyone the truth.
 
So. HAL decided to kill the crew. BECAUSE YOU CAN’T LIE TO DEAD PEOPLE.