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safe2249658 lyra heartstrings35045 human264451 pony1680888 unicorn572798 g42110219 american dad95 brian griffin88 chalkboard3783 chris griffin25 cleveland brown20 donna tubbs3 family guy784 francine smith9 hayley smith4 human studies101 with lyra293 lois griffin33 male578779 meg griffin37 meme96243 peter griffin173 rallo tubbs3 roberta tubbs2 seth macfarlane10 stan smith22 steve smith19 stewie griffin71 the cleveland show11
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Background Pony #3104
At least when Matt Groening made another show, it was completely different from the other. Seth MacFarlene has literally made the same show three goddamn times.
Squirmy Hooves
The End wasn't The End - Found a new home after the great exodus of 2012

@Beau Skunky  
Yup, even The Simpsons actually follows it. Homer is a lovable idiot, he is married to Marge who is an hot wife, Bart is not much of a loser in personality but still has bad grades, Lisa acts somewhat snarky and can seem to dislike Homer sometimes, for all we know Maggie is a sadist, and their pets do not talk but there are still friendly animals in the series.
 
Futurama is not even about a family, but a crew of a spaceship and they bring goods to aliens. And the redhead guy from the past is his own grandfather.
Beau Skunky
Friendship, Art, and Magic (2019) - Celebrated Derpibooru's seventh year anniversary with friends
Cool Crow - "Caw!" An awesome tagger
Magnificent Metadata Maniac - #1 Assistant
Artist -

Derpibooru's land-whale
Have you noticed the animated sitcoms that don’t follow this “Seth Macfarlane” formula tend to get cancelled?  
(Darn you Fox for cancelling Napoleon Dynamite!)
NotThatAnyoneCares
The End wasn't The End - Found a new home after the great exodus of 2012

“Then there was a show involving a robot chicken. Strangely, most of it consisted of short sequences of grotesque violence. Although it was presented as comedy, most humans found it disgusting.”
Redge
The End wasn't The End - Found a new home after the great exodus of 2012

Oh yeah, I forgot that American Dad existed until just now.
 
 
I’m not entirely sure that I’m glad this picture reminded me of it…