The first MANPADS (MAN-Portable Air-Defense System, like an Stinger or Igla), ever produced, if we take into consideration plain air defense, would be the Holman Projector, an anti-aircraft weapon used by the Royal Navy during WW2 (early 1940-late 1941), it was used mainly in merchant ships to create a deterrent effect, as the characteristic black puff the grenades created after detonating made the enemy pilots either think that it was more heavily defended with AAA (Anti-Aircraft Artillery) than it really was. Either making them return to avoid being shoot down or attacking with higher altitude, with a commesurate decrease in accuracy.
All this being said, the Holman Projector was usually installed on ships, instead of carried by infantry, this is one of the reasons why the german Fliegerfaust (Aircraft fist, if taken literally), a prototype of an unguided four/nine-barrelled 20mm rocket launcher designed in 1944 to damage heavily ground attack planes, is considered generally as the first MANPADS ever.